PURPOSE: Value of Information (VOI) methods provide essential tools to quantify the value of additional evidence to reduce uncertainty in decision making and inform research prioritization decisions. In this workshop, the ISPOR Task Force members present its initial good practice recommendations. We focus on the role of VOI in supporting different types of health care decisions. Members of the task force will: 1) describe sources of uncertainty that can be addressed with VOI; 2) present wide applications of VOI from multiple decision making perspectives – clarifying how results of VOI analysis can be embedded into the decision making process to inform adoption and research decisions and address issues associated with conditional coverage options; and 3) identify key steps for reporting, presenting and interpreting VOI results. DESCRIPTION: Specifically, the task force will cover three key topics: (1) VOI’s role for informing HTA conditional reimbursement decisions following recent developments of EMA’s “Adaptive Pathways” approach; (2) VOI applications through specifying a pay-off function allowing the use of different decision criteria (e.g. comparative effectiveness, cost-effectiveness, or alternative metrics not using a cost per QALY value); and (3) barriers to current application, how to overcome them, and future research directions. The workshop will be valuable to researchers, HTA agencies, decision makers, and industry analysts involved in supporting and making research decisions. The audience will participate in a real-time online poll. Following the presentation of (1) and (2) topics, feedback is requested on the recommendations. Before topic (3), participants will indicate the resources, skills, and software that they should use/require for VOI analysis and how they think these requirements may be met. Following topic (3) participants will rank the presented future research topics in order of importance, and bring forward additional topics. The workshop will conclude findings and Q&A.