TORIC INTRAOCULAR LENSES FOR THE CORRECTION OF PRE-EXISTING CORNEAL ASTIGMATISM DURING CATARACT SURGERY- A SYSTEMATIC REVIEW OF THE LITERATURE

Author(s)

Zignani M1, Caridad PV1, Ender F1, Breitkopf S2, Shaikh J3, O’Boyle D4
1Alcon Management SA, Geneva, Switzerland, 2Alcon Pharma GmbH, Frieburg, Germany, 3Novartis Healthcare Pvt Ltd, Hyderabad, India, 4Novartis Ireland Ltd., Dublin, Ireland

Presentation Documents

OBJECTIVES: Astigmatism is a refractive error typically resulting from anterior corneal asymmetry. Preoperative astigmatism ≥0.5 diopters (D) is present in 77% of cataract eyes. Toric IOL implantation corrects pre-existing corneal astigmatism, alleviating risk of residual post-operative astigmatism, an important cause of suboptimal post-operative uncorrected distance visual acuity (UCDVA) and dependency for distance spectacles post-surgery. The objective of this study was to assess and compare the quality and quantity of published evidence for toric IOLs to correct pre-existing corneal astigmatism (≥ 0.5 D) and improve postoperative visual acuity outcomes in patients undergoing cataract surgery compared to non-toric IOLs, with or without astigmatism reducing surgical interventions.

METHODS: A systematic literature review was conducted using electronic searches on Embase®, MEDLINE®, MEDLINE®-In Process, and Cochrane (January 1974 -July 2016). Articles were selected if they included adult patients, undergoing phacoemulsification, with age-related cataracts and pre-operative regular corneal astigmatism (≥0.5D). Outcomes included postoperative UCDVA, CDVA, and residual astigmatism. Quality assessment of the included studies was performed using the Centre for Review and Dissemination (CRD), York checklist.

RESULTS:

CONCLUSIONS: The evidence suggests that toric IOLs are superior to non-toric IOLs, with or without surgical interventions, in reducing postoperative astigmatism, increasing postoperative UCDVA and spectacle independence . However with 14 out of 19 RCTs the majority of evidence published to date, is based on studies including the AcrySof® toric IOL platform.

Conference/Value in Health Info

2017-11, ISPOR Europe 2017, Glasgow, Scotland

Value in Health, Vol. 20, No. 9 (October 2017)

Code

PMD13

Topic

Clinical Outcomes

Topic Subcategory

Comparative Effectiveness or Efficacy

Disease

Sensory System Disorders

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