OBJECTIVES: To explore changes in utility elicitation methods and estimates for cardiovascular disease (CVD) in recent years.

METHODS: A systematic literature review was conducted in Embase and PubMed to identify studies published between September 1992 and February 2017 reporting utilities for stroke (S), myocardial infarction (MI), and angina (stable and undefined/unstable). Grey literature was also searched. Median utility values were calculated from reported average utilities. Changes in the past 5 years (2013-2017 vs. 1992-2012) in utility methods and estimates were assessed.

RESULTS: CONCLUSIONS: CVD utility methods have changed substantially since 2012. Populations evaluated might have changed over time due to improvements in treatments, or differences in evaluated populations. A larger number of trials report EQ-5D, whereas direct methods are in decline. As direct methods can yield higher values, source and methods are important to consider.