RISK OF MAJOR OSTEOPOROTIC FRACTURE (HIP, VERTEBRAL, RADIUS, HUMERUS [MOF]) AFTER FIRST, SECOND AND THIRD FRAGILITY FRACTURE IN A SWEDISH GENERAL POPULATION COHORT
Author(s)
Jonsson E1, Ström O2, Spångéus A3, Åkesson K4, Ljunggren Ö5, Borgström F2, Banefelt J1, Toth E6, Libanati C6, Charokopou M6
1Quantify Research, Stockholm, Sweden, 2Quantify Research and LIME/MMC, Karolinska Institutet, Stockholm, Sweden, 3Linköping University Hospital, Linköping, Sweden, 4Lund University, Skåne University Hospital, Malmö, Sweden, 5Uppsala University, Uppsala, Sweden, 6UCB Pharma, Brussels, Belgium
OBJECTIVES: Fracture is an established risk factor for future fracture and important for risk-assessment, economic modelling, and treatment decision-making. We estimated the risk of subsequent MOF following first, second and third fracture. METHODS: Women ≥50 years with ≥1 fracture between 2006-2012 (index date) were identified from national registers (1998–2015) and followed from first, second and third fracture. Women with a fracture at index were matched (1:3) with non-fracture controls, based on gender and age. Fracture risk was assessed by a parametric survival spline model with subsequent MOF as failure event, and controlled for nine known risk factors (comorbidities, treatment, demographic-related). RESULTS:
Conference/Value in Health Info
2017-11, ISPOR Europe 2017, Glasgow, Scotland
Value in Health, Vol. 20, No. 9 (October 2017)
Code
PMS13
Topic
Epidemiology & Public Health
Disease
Musculoskeletal Disorders
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