PATIENT CHARACTERISTICS, SKELETAL RELATED EVENTS (SRE) AND RENAL IMPAIRMENT (RI) IN PATIENTS WITH MULTIPLE MYELOMA (MM)- A PATIENT CHART AUDIT IN EU5
Author(s)
Mateos M1, Cavo M2, Fink L3, Koneswaran N3, Giannopoulou C4, Niepel D5, Gonzalez-McQuire S5, Intorcia M4
1University Hospital of Salamanca, Salamanca, Spain, 2Bologna University School of Medicine, Bologna, Italy, 3Kantar Health, Paris, France, 4Amgen GmbH, Zug, Switzerland, 5Amgen (Europe) GmbH, Zug, Switzerland
OBJECTIVES: This multicenter patient chart review aimed to understand the characteristics, bisphosphonate (BPs) treatment patterns, SREs and RI in newly diagnosed MM (NDMM) patients in 5 EU countries. METHODS: Medical records of MM patients were screened by oncologists, (onco-)hematologists and internists from France, Germany, Italy, Spain and the UK, with ≥3 years clinical experience and managing ≥15 MM patients/month. Data were collected in June-July (France, Italy, UK) and September-November (Germany, Spain) 2016 for patients whose disease progressed following a 1st, 2nd or 3rd line (L) of treatment within the previous 3 months. RESULTS: [95% C.I.] age at diagnosis was 66 [65-66], 41% were female and 17%, 57%, 22% and 4% had an ECOG performance status score of 0, 1, 2 and 3+ respectively. Bone pain was the symptom ultimately leading to MM diagnosis in 63% of the patients, vertebral fractures in 23% and renal impairment in 23%. The majority of patients (74%) had at least 2 bone lesions and 51% had either mild, moderate or severe RI, at the initiation of 1L. 75% of all and 75% of RI patients received BPs during the entire 1L management (diagnosis to disease progression). 214 (26%) patients suffered from at least 1 new SRE during the follow-up (366 SREs overall), with a yearly SRE rate of 0.6, and 119 (15%) had SRE-related hospitalization. CONCLUSIONS: Bone pain, renal dysfunction and vertebral fractures were leading reasons for diagnosis of MM.
Conference/Value in Health Info
2017-11, ISPOR Europe 2017, Glasgow, Scotland
Value in Health, Vol. 20, No. 9 (October 2017)
Code
PCN11
Topic
Epidemiology & Public Health
Disease
Musculoskeletal Disorders, Oncology