IMPACT OF DISEASE ACTIVITY MEASURES ON HEALTH UTILITIES IN PPMS
Author(s)
Daigl M1, Jhuti GS1, McDougall F2, Bennett I1
1F. Hoffmann-La Roche Ltd, Basel, Switzerland, 2F. Hoffmann-La Roche Ltd, Welwyn Garden City, UK
OBJECTIVES: To evaluate the impact of disease activity measures on health utilities in PPMS patients. METHODS: In the ORATORIO phase III clinical study 732 PPMS patients were randomized in a 2:1 ratio to treatment with ocrelizumab 600mg or placebo. Expanded Disability Status Scale (EDSS), 9 Hole Peg Test (measure of upper limb function), the Modified Fatigue Impact Scale (MFIS), and EuroQol five dimensions questionnaire (EQ5D) were all assessed at baseline, 48 and 120 weeks. The relationship between the disease activity measures and EQ5D was investigated and the best selected model was a repeated measures linear model that regressed health utilities on EDSS states, clinically significant fatigue and upper limb impairment. Analyses were performed using utilities scores derived with the Australian, British, Canadian, Dutch, French, Italian, Portuguese and Swedish value sets. RESULTS: Health utilities were found to be inversely associated with EDSS state: higher EDSS scores were associated with lower utility scores. Utilities were further associated with fatigue with a disutility between 0.13 (95%CI:0.11-0.15) for the Portuguese and 0.07 (95%CI:0.06-0.08) for the Swedish analysis, and upper limb dysfunction for EDSS from 5 and above with a disutility between 0.06 (95%CI:0.02-0.10) for the Portuguese and 0.02 (95%CI:0.00-0.03) for the Swedish analysis. CONCLUSIONS: In addition to higher EDSS scores, both fatigue and upper limb dysfunction were associated with independent impacts on health utilities in PPMS patient. This is the first study quantifying the impact of multiple symptoms/factors in a large cohort of PPMS patients using country-specific value sets.
Conference/Value in Health Info
2017-11, ISPOR Europe 2017, Glasgow, Scotland
Value in Health, Vol. 20, No. 9 (October 2017)
Code
PND59
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
Neurological Disorders