ECONOMIC EVALUATION OF ALTERNATIVE MEASLES-MUMPS-RUBELLA CHILDHOOD VACCINATION SCHEDULES IN DENMARK
Author(s)
Nymark L
Aarhus University, Aarhus C, Denmark
OBJECTIVES: To determine the economic impact of alternative measles-mumps-rubella (MMR) childhood vaccination schedules in Denmark when considering avoided hospitalizations for any infectious disease. METHODS: A Danish register-based study of the average cost per any infectious disease hospitalization in Danish children, dependent on vaccination status and age in months was performed. The age dependent risk of any infectious disease hospitalization and the average cost per any infectious disease hospitalization were combined in a decision analytical model and the cost associated with moving the recommended time of MMR vaccination at 15 months-of-age and 4 years-of-age (schedule A; the base-case) forward in schedules B: 13 months-of-age and 15 months-of-age, C: 6 months-of-age and 15 months-of-age and D: 6 months-of-age and 13 months-of-age was examined; assuming coverage rates as in the current vaccination schedule. Scenario analyses of the cost of MMR vaccination in different programmes and at different coverage rates of MMR vaccination were performed.
RESULTS: In the base case, the decision analytical model predicts undiscounted incremental savings in schedules B, C and D compared to A. The largest incremental saving was found in schedule D with a saving of 14.9 million DKK, followed by schedule C (11.3 million DKK) and B (5.1 million DKK). The incremental undiscounted savings were sensitive to increasing the MMR vaccination coverage to 95% from A actual coverage rates in schedules A, B, C and D. Increasing coverage rates to 95% in schedule A would require an additional 10.5 million DKK for vaccinations but could lead to 8.8 million DKK in savings on hospitalizations, resulting in -1.7 million DKK. Changing coverage to 95% generated incremental savings and the savings were highest for D (17.3 million DKK), then C (12.6 million DKK) and B (3.1. million DKK).
CONCLUSIONS: The study suggests that alternative MMR vaccination schedules are associated with savings.
Conference/Value in Health Info
2017-11, ISPOR Europe 2017, Glasgow, Scotland
Value in Health, Vol. 20, No. 9 (October 2017)
Code
PIN49
Topic
Economic Evaluation
Topic Subcategory
Cost-comparison, Effectiveness, Utility, Benefit Analysis
Disease
Infectious Disease (non-vaccine)
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