OBJECTIVES: To show the complexity of patients with Parkinson’s disease (PD) by illustrating an accurate profile based on the prevalence of depression and other complications, as well as differences observed among patients from UK and USA, for further good practices recommendations. METHODS: A cross sectional descriptive study was conducted using an electronic survey among patients from UK and USA diagnosed with PD. Patients (n=104) were screened for depression by using the Zung Self-Rating Depression Scale (ZSDS). Prevalence of movement and nervous system symptoms was assessed by using multiple choice questions and the distress of each category was scored from 0 to 3 (0–no, 1–mild, 2-moderate, 3-severe) where a higher score indicates greater distress. Comparisons between patient groups were made with ANOVA and two-tailed t-test, correlations were interpreted based on calculations of Pearson’s R and descriptive statistics summarized the features of the sample. RESULTS: Most of the patients were from UK (65.38%), 50.96% were female and 54.81% showed depression according to the ZSDS. Comparisons between UK and USA patient groups disclosed no significant differences (all p>0.05). Patients aged 40-50 showed a higher incidence of depression and a more severe stage (p=0.025<0.05). Prevalence of movement and nervous system symptoms as well as the distress of these symptoms are up to two times higher in patients with depression than in those without (p<0.05). In patients with depression according to the ZSDS, 50.88% consider themselves not being depressed and in those that do not have depression according to the ZSDS, 14.89% consider themselves depressed. CONCLUSIONS: All patients with PD revealed a complex profile and require good management of frequent comorbidities. Prevalence of depression calls for medical professionals to be vigilant in the screening process.