OBJECTIVES: : Stroke has been considered as one of the most common neurological disease life-threatening and a global health problem. It causes disability in adults and ranked as the third leading causes of human mortality worldwide. The aim of this study was to compare the quality of life in Stroke’s patients in both treated and not treated groups with (rt-PA).

METHODS: We conducted a cohort study on 126 stroke attacked patients, 42 and 84 patients treated and not treated with (rt-PA) respectively. We used a disease specific questionnaire for stroke (SSQOL) and generic questionnaire (EQ5D) . The patients were studied from the first week of treatment and continued up to 3 months after completion of the therapy (treatment with and without rt-PA), followed up and then complete the questionnaires. Both groups were tested for significant differences regarding socio-demographic. A multiple linear regression model was implemented to find out the factors affecting different aspect of QOL among the patients.

RESULTS: stroke attacked group was differ in physical and mental health, composite scores as well as relative scales. There was a significant difference between the MRS and NIHSS scores in the two groups Stroke’s patients treated and not treated with (rt-PA) after 3 months(p < 0.05). Quality of life in patients treated with (rt-PA) was ./67 and in patients treated with No-(rt-PA) was ./07.

CONCLUSIONS: By this study, we can conclude that a significant differences between QOL of patients were occurred when treated with (rt-PA) in compare with not treated with (rt-PA). In over all we can say (rt-PA) improved the quality of life in stroke attacked patients significantly. This study suggests that (rt-PA) improved the quality of life in stroke attacked patients by improving the sleep patterns, physical, social and psychological conditions.