OBJECTIVES : To describe the demographics, treatment history, and secukinumab usage patterns of patients with psoriatic arthritis (PsA) who initiated secukinumab in a real-world setting in the United States.

METHODS : This study analyzed service request forms (SRFs) jointly filled by patients with PsA and their health care providers at the time of secukinumab initiation from January 15, 2016, to December 31, 2016. Patient demographics, treatment history, and secukinumab usage (initiation and maintenance dose) were analyzed descriptively. Categorical variables were summarized as number and percent of patients; continuous variables were summarized by means and standard deviations.

RESULTS : A total of 4164 patients with PsA with secukinumab SRFs from 1708 unique providers were included. Patients were from all regions of the United States (Northeast, 19.3%; North Central, 15.7%; South, 44.7%; West, 16.1%; Puerto Rico/Virgin Islands, 0.4%); approximately 60% of patients were female and the mean (SD) age was 53.6 (12.0) years. Overall, 6.1% of patients were biologic naive, 41.9% received ≥ 1 prior biologic therapy, and 52.0% had missing information about prior biologic use. Among patients with prior biologic use, 38.6% had 1 reported biologic efficacy failure, 33.8% had 2 efficacy failures, and 27.7% had ≥ 3 efficacy failures; the most commonly reported biologic efficacy failures were adalimumab (67.4%) and etanercept (59.1%). For both initial and maintenance dosing, approximately half of patients were prescribed secukinumab 300 mg (51.1% and 51.6%, respectively).

CONCLUSIONS : In this analysis of SRFs filled by patients with PsA and their health care providers, approximately half of patients were prescribed secukinumab 300 mg for both initial and maintenance dosing. These results provide early insights into the prescribing patterns of secukinumab for PsA in a US real-world setting. Future research is needed to better understand how clinical characteristics and treatment history may affect secukinumab usage in US patients with PsA.