Author(s)
Kim CJ1, Yoo B2, Kim B3, Choi JW4, Kim D5, Lee SH6, Song W7, Jeon D8, Cha T9, Kim D10, Lim S11, Nam C12, Shin J13, Kim W14, Kwak J15, Park J16, Cha J17, Kim Y17, Lee JY18, Choi JM18
1Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of (South), 2Wonju Severance Christian Hospital, Yonsei University Health System, Wonju, Korea, Republic of (South), 3Kangbuk Samsung Hospital, Seoul, Korea, Republic of (South), 4Eulji General Hospital, Seoul, Korea, Republic of (South), 5Inje University Haeundae Paik Hospital, Busan, Korea, Republic of (South), 6Severance Hospital, Yonsei University Health System, Seoul, Korea, Republic of (South), 7Korea University Ansan Hospital, Ansan, Korea, Republic of (South), 8National Health Insurance service Ilsan Hospital, Goyang, Korea, Republic of (South), 9Kosin University Gospel Hospital, Busan, Korea, Republic of (South), 10Inje University Busan Paik Hospital, Busan, Korea, Republic of (South), 11Dankook University Hospital, Cheonan, Korea, Republic of (South), 12Keimyung University Dongsan Hospital, Daegu, Korea, Republic of (South), 13Ajou University Hospital, Suwon, Korea, Republic of (South), 14Yeungnam University Hospital, Daegu, Korea, Republic of (South), 15Inje University Ilsan Paik Hospital, Goyang, Korea, Republic of (South), 16Seoul National University Hospital, Seoul, Korea, Republic of (South), 17Pfizer Pharmaceuticals Korea Ltd., Seoul, Korea, Republic of (South), 18Korea University College of Medicine, Seoul, Korea, Republic of (South)
OBJECTIVES : This aimed to assess treatment patterns and medication adherence and to compare clinical(BP control) and Patient-Reported Outcomes(treatment satisfaction and quality of life, QoL) by treatment patterns and medication adherence at 6-month among uncontrolled hypertensive(HTN) patients of Korea. METHODS : A prospective,observational,non-interventional study was conducted at 16 nationwide, tertiary hospitals. Uncontrolled HTN patients(SBP≥140mmHg or DBP≥90mmHg) were enrolled during 2015-2016 and studied for following 6-month. Data collection was performed through medical chart review and patient survey. Treatment patterns were used to examine whether physicians followed guideline-based practice(GBP) which was defined if one of followings was met;1)maximize first medication before adding second or 2)add second medication before reaching maximum dose of first medication. Medication adherence was investigated with Morisky Medication Adherence Scale-8(MMAS-8) with 3-level of adherence(high,medium,low) and patients were further categorized adherent if they showed high adherence. Treatment satisfaction was assessed using treatment satisfaction questionnaire for medication-1.4(TSQM 1.4) consisting of 4-domain(effectiveness,side-effects,convenience,global satisfaction).EuroQoL-Visual Analogue Scale(EQ-VAS) was used to examine QoL. RESULTS : A total of 600 patients included. Of the total, mean age was 58.6±13.4 and male were 55.7%. Portions of adherent patients and patients who received GBP were 49.2% and 67.4% at 6-month, respectively. Overall BP control rate was 34.6% and differed by GBP and adherence status at 6-month. Higher BP control rate was present in patients who were on GBP and also adherent than those on GBP, but not adherent, or non-GBP patients(76.8%vs.71.9%vs.53.6%, p-value<.0001). Better treatment satisfaction found in GBP and adherent patients comparing to GBP and non-adherent or non-GBP patients(effectiveness:66.5±12.0vs.62.4±13.6vs.61.4±12.6, side-effects:99.5±4.2vs.97.5±10.5vs.99.2±5.8, convenience:72.1±10.1vs.64.2±12.6vs.65.3±11.7, global satisfaction:65.7±12.1vs.60.7±14.3vs.59.1±13.7, all p-vales<0.05). For EQ-VAS, GBP and adherent patients showed better QoL than GBP with non-adherent or non-GBP patients(77.6±11.7vs.74.2±14.1vs.74.1±13.7, p<.0001). CONCLUSIONS : This highlights the importance of GBP and patient-reported adherence to improve BP control, treatment satisfaction, and QoL.
Conference/Value in Health Info
2018-05, ISPOR 2018, Baltimore, MD, USA
Value in Health, Vol. 21, S1 (May 2018)
Code
PCV69
Topic
Patient-Centered Research
Topic Subcategory
Adherence, Persistence, & Compliance, Patient-reported Outcomes & Quality of Life Outcomes, Stated Preference & Patient Satisfaction
Disease
Cardiovascular Disorders
