PURPOSE: To increase awareness of new developments in value-based payment (VBP) arrangements and value demonstration in Latin American health systems. Increasing healthcare costs—and particularly for innovative medicines—are a growing concern in Latin American countries. Value-based pricing and payment have been proposed as one of the strategies to improve outcomes while controlling costs. The proposed cost-containment strategies include: risk-sharing arrangements, outcomes-based contracting, and high-cost drug funds. These are in addition to the use of health technology assessment, pharmacoeconomic guidelines, reference pricing, and care pathways. Meanwhile, health plan administrators and industry executives are exploring the full range of these options in an effort to understand VBP applicability in regional healthcare systems. In this proposed workshop, speakers from academia, pharmaceutical industry, and international organizations will describe and discuss the history, current development, and trends in VBP in Latin American markets. Lessons from other regions will also be presented. The final 15 minutes of the workshop will be devoted to discussion and Q&A with the audience about future developments of VBP in the region.