OBJECTIVES

To estimate the disease burden of lysosomal deposit pathologies: Fabry, Gaucher and Hunter Syndrome.

METHODS

through a Markov model, the DALYs were estimated by sex and age cycle in Colombian patients with any of the three diseases. Weights derived from disability were estimated using data from the global report. The information was obtained from literature review, experts and Funservir (Colombian Foundation for patient management). The sociodemographic conditions and the epidemiology of the diseases were characterized

RESULTS

It was observed for patients with Fabry, higher prevalence in men, a general life expectancy (GLE) of 67 years (six years less than the national average), with a weight derived from disability (WDD) because of the disease of the 56%, a rate of DALYs of 59.07 /10 hab., Being higher is lost in men with ages between 30 and 34 years, and a male-to-female ratio of 2.4: 1; in the total of healthy life years potentially lost by the disease.

In Gaucher, the prevalence is higher in men with a slight difference compared to women, GLE of 68 years, a WDD of 57.4%, a rate of DALYS of 77.16 /10 hab., Higher in men with age between 45 and 59 years old and a male-female ratio of 1.1: 1.

For Hunter syndrome, all cases are in men, GLE of 55 years, a WDD of 60% and a rate of DALYs of 41.6 /10 Hab., Having the highest loss in people under 14 years.

CONCLUSIONS

the results provide a comparable estimate with pathologies of high prevalence and national burden of disease such as hypertensive heart disease and depression.

The results are of high impact for public health, given that in Colombia there are no studies of this type.