OBJECTIVES: Assessment of productivity loss caused by RA, CD and psoriasis and comparison differences in Poland. METHODS: The participants of the M2W study were consecutive patients with diagnosed RA, psoriasis and CD, in productive age (women 18-60, men 18-65), recruited at regionally stratified sample of 89 outpatient centers (rheumatology, dermatology or gastroenterology). 814 RA, 464 CD and 822 Ps patients with dominantly low or moderate disease activity were assessed. Productivity loss was measured using Work Productivity and Activity Impairment (WPAI) questionnaire which included presenteeism, absenteeism and overall work impairment (OWI) indexes. Additional questionnaires on patients’ characteristics and disease activity level, assessed on standardized scales: DAS28, PASI, CDAI, were added. Present economic activity (% of workers), presenteeism (time lost due to inefficient work), absenteeism (time of temporal absence caused by disease) and OWI ratios were calculated for each diagnostic group separately. RESULTS: Of the three groups, patients with RA had the lowest rate of economic activity – 42%. 56% of CD patients and 57% of Ps patients worked for pay. Furthermore, productivity loss measured with OWI was highest in RA group: 43% of work time was lost. It was slightly better in CD and Ps groups, OWI amounted to 36% and 35% respectively. RA group had the highest absenteeism rate (18%) and also high presenteeism rate (27%), Ps group had the lowest absenteeism rate (9%) and the highest presenteeism rate (28%), CD group ranked between them with 16% absenteeism rate and 24% presenteeism rate. CONCLUSIONS: RA, CD and Ps all cause productivity loss, each in a different manner. M2W study is a unique national data source for indirect cost analysis for RA, CD and psoriasis.