OBJECTIVES: Validate the use of Fact-Lym and Facit-Fatigue as instruments measuring of health related quality of life (HRQoL) of patients with myeloproliferative syndromes for Colombia. METHODS: Under mean prevalence data of myeloproliferative syndromes in Colombia ranging from 0.3 to 1.5 per 100,000 people, was estimated a simple random sample of 46 patients distributed throughout the country to develop validation of measuring instruments : (i) Fact-Lym scale, (ii) Facit-fatigue scale. As a comparison scale items, was applied a vision analogous scale (VAS), wich assessed the homogeneity of the questions by averaging all correlations between all items to see effectively will be consistent. Translations of the instruments were not needed as these are in Spanish language. RESULTS: From a total of 46 respondents, 2.17% was not able to answer. Through each having dimensions of the scales, Cronbach's alpha coefficient was estimated using the results of the VAS, obtaining a 84.19 alpha coefficient for overall fitness, 87.00 for family and social environment, 64.3 for emotional state, personal functioning 78.17, other concerns 90.82 and  to the level of fatigue 92.53. Results suggest high levels of reliability above 75% (except the dimension of emotional state) of the scales and the results obtained through this. CONCLUSIONS: There is a strong correlation between the scores of the items of the Fact-Lym and Facit-fatigue scale regarding the estimate of Cronbach's alpha coefficient, thereby it's considered reliable for use in patients with myeloproliferative syndromes in Colombia.