STUDY ON MECHANISM OF TYPE 2 DEIODINASE GENE AND ERK SIGNAL TRANSDUCTION IN KASHIN-BECK DISEASE
Author(s)
Xiong Y1, Song R2, Jiao X2, Du X2, Liu J2, Liu X2, Chen Q2
1Xi’an Jiaotong University Health Science Center, Xi’an, China, 2Xi'an Jiaotong university, Xi'an, China
OBJECTIVES: Kashin-Beck disease (KBD) is an endemic, deformable, and chronic osteoarthropathy prevailing in selenium (Se)-deficiency regions, while its etiopathogenesis maintains obscure. Type 2 Deiodinase (DIO2) is an important Se-dependent antioxidant enzyme and there are many polymorphisms in DIO2 gene, among which, Thr92Ala（rs225014）has been studied widespread in diseases. In many different cells, ERK signalling pathway palys a role in anti-apoptosis and decreased ERK activity is necessary for apoptosis. Therefore, we investigated possible association between DIO2 Thr92Ala and susceptibility to KBD in a Chinese population.To explore molecular mechanism of cartilage apoptosis and role of Se in prevention in KBD, expression of signal molecules of ERK pathway in controls and KBD patients are detected and NaSeOare added to explore it’s effect on ERK pathway. METHODS:
Conference/Value in Health Info
2014-05, ISPOR 2014, Palais des Congres de Montreal
Value in Health, Vol. 17, No. 3 (May 2014)
Code
PMS13
Topic
Epidemiology & Public Health
Disease
Musculoskeletal Disorders