OBJECTIVES: Web-based interventions are promising smoking cessation tools. We are testing the effectiveness of Transition2Quit, a tailored web-based and e-message program for hospitalized smokers, versus usual care (minimal advice through non-tailored printed materials). We present data on resources to implement Transition2Quit. METHODS: Interventionists approached smokers during hospitalizations to register and orient them to the website (onsite registration). Staff made ≥ 5 attempts at a follow-up contact 7-14 days post-discharge. Through the website, we tracked follow-up calls and web activity. Interventionists recorded start and finish times of their activities. RESULTS: Of 737 smokers, 54.4% were male, 27.4% had cancer, 29.2% heart disease/stroke, 13.3% lung disease, 15.6 surgery or wound healing, and the rest other conditions. Mean age was 41.6 years. Onsite registration lasted 8-41 minutes (mean 17.6, median 16, SD 8.23), usual care 0-6 minutes (mean 2, SD 1). Interventionists attempted 2.9 calls per person (SD 1.9, max 9).  129 participants could not be reached due to disconnected phones, death, or ≥ 5 call attempts. For 43.4% ≥1 call was placed on weekends, for 69% in the evening. Follow-up calls lasted an average of 2.4 minutes (median 3, SD 0.9). 700 participants accessed the website 15.4 times (SD 17.1), on 1.98 days (SD 3.39), and accessed 5.39 pages (SD 4.06). Women were more likely to access the website than men (16.9 vs 14.2, p 0.04). Participants with heart disease accessed 18.4 times (SD 23.6), with cancer 15.4 (SD 13.8), with surgery or wound healing 15.2 (SD 13.0), with lung disease 12.9 (SD 10.7), with other condition 12.2 (SD 14.5) (p=0.018). CONCLUSIONS: Transition2Quit required minimal staff resources: to better inform dissemination, further understanding on how requirements vary depending on populations’ characteristics (e.g., age, health condition) is needed.  The website content may need to be better tailored to men and lung disease patients.