OBJECTIVES: To perform a qualitative patient interview study using an internet-based digital patient platform for recruitment and telephone and webcam for interviews. METHODS: To design the qualitative study we followed the steps outlined in the ISPOR PRO Good Research Practices Task Force Report: Part 1 (Patrick et al, 2011). Briefly, a qualitative interview guide was developed and approved by IRB.  Participants were recruited, consented, enrolled, and interviewed online. Each interview was audio recorded and transcribed. Analysis of the qualitative data was performed by experienced market researchers.  RESULTS: Screening, demographic, and medical information was gathered directly from patients online, via the internet, with no interaction from the patient’s physician(s) or site. Existing members of MediGuard, an online free medication monitoring service, were sent an email invitation to participate in the study. Members who choose to click on the link were directed to a website where they accessed information regarding the study, provided consent to participate, self-screened for eligibility, and reported baseline characteristics. Consented participants were contacted via phone to schedule a time to participate in an individual interview via telephone or webcam.  Interviews were audio recorded, and lasted 60-75 minutes. 17 patients were interviewed.   CONCLUSIONS: Recruiting and interviewing patients via the internet and phone is a feasible, faster, and potentially lower cost alternative to face to face interviews. Some benefits of direct to patient research include potential to reduce patient travel burden to a study site and access to patients who are home bound or located in remote geographic locations. This novel approach did not seem to alter the participant’s ability to participate in a qualitative study.