OBJECTIVES: The objective of this study was to describe the prescription pattern of antipsychotics among schizophrenia patients in a psychiatric hospital. The secondary objective was to describe the patient characteristics. METHODS: A retrospective observational study was conducted from January, 2010 – January, 2011. All patients with a clinical diagnosis of schizophrenia who had been hospitalized during the study period were followed for one year post-hospitalization. Data on patient demographics, disease onset, clinical diagnosis, prescription medications and clinical outcomes were obtained from the medical records. Outcomes were defined as per medical records as improved or unchanged upon discharge.  RESULTS: Thirty patients were hospitalized from January 2010 to January 2011 with a clinical diagnosis of schizophrenia. The population was unequally distributed in terms of gender. The mean age of the patients was 36.66 ± 9.24 years. Most patients [n = 17(53%)] had a family history of schizophrenia. Paranoid schizophrenia was the most common diagnosis among patients [n=15 (50%)] followed by un-differentiated schizophrenia [n= 4(13.3%)], simple schizophrenia [n=2 (13.3%)], catatonic schizophrenia [n=2 (13.3%)], hebephrenic schizophrenia [n=2 (13.3%)].  Monotherapy with respect to antipsychotics was seen among a majority of the patients [n= 17(56.66%)]. Second generation antipsychotics (SGAs) were prescribed regardless of mono-therapy or combination therapy. Risperidone [n=17 (56.7%)] was most frequently prescribed, followed by aripiprazole [n=7 (23.3%)] and olanzapine [n=5 (16.7%)].  Haloperidol was the predominant first generation antipsychotic (FGA) prescribed [n= 3(10%)].  Of the patients on combination therapy [n=12], most [n=10 (83.3%)] were on combination of two or more SGAs. A majority [n= 18(60%)] of the patients had an unchanged outcome at the time of discharge. CONCLUSIONS: The results of the study indicate that the therapy prescribed does not meet the clinical goals for the patients. A larger study is required to assess the prescription patterns and the predictors of outcomes among schizophrenics in the Indian population.