OBJECTIVES: As of December 2013, there were over 20 drugs available in the US for the treatment of POS.  The aim of this study is to understand the remaining burden of disease and the need for newer treatments. METHODS: Data from the 2012 and 2013 U.S. National Health and Wellness Survey (NHWS) was analyzed. The NHWS is self-administered, internet-based survey of a nationwide sample of adults (18+ years) stratified to represent the demographic composition of the U.S. population. Patients self-reported a diagnosis of epilepsy with POS and were grouped as uncontrolled (>= 1 seizure per month) and controlled (<1 seizure per month). Patients provided information on health status (mental (MCS), physical component summary (PCS), and SF-6D (health utility) scores from the SF-36v2), resource utilization in the past six months and treatment satisfaction with current epilepsy prescription medication (1 [extremely dissatisfied] to 7 [extremely satisfied]). Regression modeling controlled for covariates. RESULTS: Among 207 diagnosed epilepsy with POS patients, 38.6% were uncontrolled and 61.4% were controlled. Uncontrolled vs. controlled patients were similar in age, gender and ethnicity, but were more likely to be in a committed relationship, less educated, and employed (p<0.05). Uncontrolled vs. controlled patients had lower health utilities (0.66 vs. 0.70, p=0.015), MCS scores (43.05 vs. 47.10, p=0.008), and non-significant PCS scores (47.95 vs. 49.12, p=0.371).  Uncontrolled vs. controlled patients reported more emergency room visits (207.7%, p=0.002), hospitalizations (447.9%, p<0.001), and traditional provider visits were non-significantly greater (22.8%, p=0.197). Amongst treated patients, treatment satisfaction was lower for uncontrolled vs. controlled (5.27 vs. 5.86, p=0.01). CONCLUSIONS: Despite the availability of existing anti-epileptic drugs (AED) in 2013, the results suggest a significantly higher economic and humanistic burden in patients with uncontrolled seizures.  POS patients are very much in need of additional treatment options for which newer AEDs may provide a solution.