OBJECTIVES: To describe the frequency and nature of patient-reported outcome (PRO) conversations between physicians and patients with Cystic Fibrosis. METHODS: A random sample of de-identified patients with Cystic Fibrosis  in the United States was selected from a large de-identified database of medical office visit transcriptions. Transcriptions were based on physician-dictated voice recordings detailing every individual patient encounter/visit. De-identified medical visit transcriptions were analyzed to evaluate the burden associated with Cystic Fibrosis, as depicted by PRO topics observed in patient-physician dialog in the real-world practice setting. Descriptive statistics are reported. RESULTS: CONCLUSIONS: PROs, as a function of disease burden, were routinely discussed by patients with Cystic Fibrosis. PRO discussions were observed more frequently among adult patients than the pediatric patients, and symptom-related PROs were discussed more frequently than PROs related to quality of life and psychosocial impacts. Modalities to alleviate this patient burden, including appropriate therapeutic interventions, warrant scrutiny.