OBJECTIVES: To study the effect of nocturnal and daytime non-severe hypoglycaemic events on the utilisation of healthcare services and patient quality of life in Mexico. METHODS: People with diabetes from six different countries who had experienced a self-reported non-severe hypoglycaemic event in the past 4 weeks were eligible to take part in a nocturnal (N) and/or daytime (D) hypoglycaemia survey. In the Mexican cohort, 77 people responded (50 for the nocturnal survey; 50 for the daytime survey). The surveys were conducted either face to face or online. RESULTS: In the Mexican subgroup, 82%/80% (N/D) of respondents had type 2 diabetes, 38%/42% (N/D) were male, mean age was 52 years/53 years (N/D), and mean weight was 74.4 kg/75.6 kg (N/D). Respondents received treatment with insulin (32%/38% [N/D]), oral medication (95%/95% [N/D]) and/or diet and exercise (49%/58% [N/D]), and 70%/76% considered themselves in good health. Non-severe hypoglycaemic episodes were experienced at least once weekly by 34%/44% (N/D) and at least once a month by 76%/68% (N/D) of respondents. After a hypoglycaemic event, 41%/16% (N/D) of respondents decreased their insulin dose, 50%/58% contacted a healthcare professional, and, in the following week, used on average 2/5 (N/D) extra blood glucose strips. Almost half of respondents reported a high level of fear of hypoglycaemic events (46%/46% [N/D]). Following a nocturnal hypoglycaemic event, mean time to return to sleep was 89 minutes, 11% did not go back to sleep at all, and 38% reported the nocturnal event had a high impact on their quality of sleep. Of respondents who worked for pay (n=23/21), 30%/67% (N/D) went to work late or left early, and 13%/24% (N/D) missed ≥1 full working day. CONCLUSIONS: In Mexico, nocturnal and daytime non-severe hypoglycaemic events severely impact quality of life, quality of sleep and productivity in people with diabetes.