OBJECTIVES: This study aims to review whether there is a match between how psoriasis patients perceive their quality of life and how this is perceived by their treating physicians. METHODS: A cross-sectional survey of Rheumatologists/Dermatologists (n = 114) and their psoriasis patients (n = 689)  living in the USA, conducted June/September 2013. Each specialist completed a comprehensive record form on patients consulting for their psoriasis. Patients were invited to complete a questionnaire and also the EQ-5D-5L instrument. Physicians completed the same instrument for how they envision the status of that same patient. Patients were split into 3 equal groups based on their health utility scores. RESULTS: No significant correlation was found between the patient- and physician-reported health utility scores (Pearson correlation index = - 0,071, p = 0.396).  In 34% of the cases there was a significant (>1x standard deviation) mismatch between the physician and the patients’ point of view. Out of that 34%, 20% was an overestimation (physicians scored the patients worse than the patients scored themselves) and 14 % was an underestimation (patients scored themselves worse than the physicians scored them).  In 15% of the cases there was a perfect match (patients and physicians generated the same health utility score). Mismatching was most frequent in the group with the lowest health utility scores. CONCLUSIONS: There is no significant relationship between health utility scores generated by physicians and patients. Although the evaluated patient is the same, there appears to be a mismatch in perception of patient wellbeing.