OBJECTIVES: To investigate the association between depression and comorbid obesity and hypertension in US children over a 8-year period using data from the National Health and Nutritional Examination Survey among those with depression or hypertension. METHODS: We built a logistic regression model using a sample of 727 respondents aged 0-18 between 2005 and 2012. RESULTS: Out of 727 subjects, 49.2% were female, 50.1% were male, 11.5% were between the ages of 0-5, 37.8% between the ages of 6-10, 26% between the ages of 11-15, 24.5% between the ages of 16-18, 28.7% were White, 71.3% were non-White,16.4% were obese and 3.6% had hypertension.  Obesity and hypertension are significant predictors of depression. Children who are obese are about 2.9 times more likely (p=0.005) to be depressed than children who are not obese, and children who suffer from hypertension are approximately 4.6 times more likely (p<0.001) to experience depression than those who do not have hypertension. Other significant predictors of depression in children are gender (p<0.001; OR=0.486) and family size (p=0.06; OR=0.673). CONCLUSIONS: Obesity and hypertension are associated with depression after controlling for other factors. This finding has important implications for depression management in children. It brings into focus the maintenance of a healthy body mass index (BMI) in mitigating depression.