OBJECTIVES: To assess health care resource utilization and cost of cervical cancer from the perspective of British Columbia’s health care system. METHODS: Retrospective observational data on women diagnosed with cervical cancer between 2004 and 2009 was utilized to calculate patient-level resource utilization from diagnosis to death or 5-year discharge. Domains of resource use included hospitalization, chemotherapy, radiotherapy, brachytherapy, medically necessary services such as laboratory, physician and diagnostics billed under B.C.’s Medical Services Plan and medication dispensed under B.C.’s Pharmacare program. Unit costs were applied to health care resources, producing per-patient costs. Relevant costs, presented in 2012 CDN dollars, were further separated by chemotherapy protocol, stage at diagnosis, screening history, progression date and age. RESULTS: The average cost of treating cervical cancer in B.C. was $32 023, (95% CI: $29 785 - $34 260). Hospital costs were the largest proportion of cost at a mean proportion of 37.8% (95% CI: 35.8, 39.8) of total cost.  Mean length of inpatient hospital visits was 11.2 days, with 2 outpatient hospital visits per patient. Costs were also calculated by relevant clinical subgroups, including progression, age, stage, screening history and treatment protocol on cost and resource utilization. CONCLUSIONS: Cervical cancer resource utilization and costs are substantial in B.C.’s health care system. Such data is necessary for decision makers in designing and implementing screening and disease management policy. Results will provide inputs for the HPV FOCAL Study, a prospective investigation into the cost-effectiveness of utilizing the detection of HPV infection as a primary screening tool in B.C.