OBJECTIVES: To identify proportion of radiology Health care professionals’ opinions regarding level of difficulty in conducting research in radiology and to ascertain barriers associated in conducting research activities in field of radiology. METHODS: :Cross-sectional analytical study was conducted during International Conference organized by Radiological Society of Pakistan in November 2009 at Sheraton Hotel, Karachi. Data were collected using a structured, self-administered questionnaire from participants willing to participate in research registered for Annual Radiology Research Workshop piloted during conference; via non-probability convenience technique. Data were analyzed using SPSS versions 19.0.Means±SD were computed for quantitative and proportions calculated for qualitative variables. Chi square and Fisher Exact tests applied for categorical variables. A p-value of < 0.001 was considered significant. RESULTS: Response rate was 76% (n=78/103), 65.4% agreed that conducting research in the field of radiology is difficult. Most of the participants (69.2%) who had not published papers believed that research in radiology is difficult as compared to those who had published a paper (30.8%) (p=0.026). However, age, sex, attending conferences and presenting papers did not significantly influence response of participants. The top three barriers in conducting research in field of radiology were time required to provide clinical services (92.3%), lack of dedicated time for research (91.0%) and diminished income in research (88.5%). Although similar responses were observed among residents and consultants regarding barriers in conducting research, more residents than consultants believed that lack of support from dean (p=0.037) and diminished income in research activities (p=0.003) were significant barriers.  CONCLUSIONS: Most of the participants’ opinion was that conducting research in field of radiology is difficult. Time required providing clinical services, lack of dedicated time for research, diminished income in research activities were identified as most important barriers in conducting research. Similar responses were observed among residents and consultants regarding barriers in conducting research.