OBJECTIVES: The traditional and complementary medicine (T&CM) is an important component of healthcare system to improve the health and the quality of life of patients. However combination of T&CM in Thalassemia care has not been explored well. The current study aimed to evaluate Thalassemia patient’s perceptions towards the combinationof T&CM with conventional therapies. METHODS: Qualitative interview were used to explore the phenomena which allows to understand the subjectivity and complexity of human experience. A total of 21 consented patients were recruited from Thalasaemia Society of Kedah State, Malaysia. Patients were from the two major ethnic groups in Malaysia namely Malay and Chinese. All interviews were conducted in Bahasa Malaysia (National Language of Malaysia) and were translated into English for thematic content analysis. RESULTS: Patients reported mixed perceptions regarding the combination of T&CM into the conventional treatment. Patients agreed such combination only been undertaken with the consent of their health care providers. However majority of the patients reported that they were never asked by their physicians regarding such combinations. This was given as a reason of not disclosing T&CM use to the doctors by some of the participants.Majority of the patients were in favour of the combination between modern and traditional medicines.Even though such combination could not cure thalassaemia, it was able to reduce the side effects of therapies used in modern therapies. CONCLUSIONS: In conclusion, the positive views of the combination of T&CM in conventional care invites doctors and nurses to have an open discussion on T&CM with their patients. This could prevent them with drug-drug interactions and may help them to use proven T&CM with least side effects. At the same time an open discussion between modern and traditional practitioners is warranted to enable combining traditional therapies in Thalassemia care in order to improve the quality of life these patients.