PURPOSE: This workshop will discuss the application of value of information (VOI) methods in coverage with evidence development (CED) schemes, where access to the new technology can be only guaranteed in face of new evidence. We will address the policy implications of the VOI methods for both industries and payers in order to support them in setting an optimal CED scheme. DESCRIPTION: CED has become increasingly popular to address uncertainties and to secure ongoing coverage for promising technologies at time of launch. VOI provides a robust framework to quantify the uncertainty and to analyze its consequences. However, to date few countries beyond the Netherlands use VOI to inform the nature of evidence to be developed. VOI methods have been recommended in The Netherlands (ZIN) with guidelines developed for implementation. By mimicking a real discussion about a virtual case study between the industry and the payer, we will enlighten participants on challenges and solutions when implementing VOI. Leyla Mohseninejad will represent the industry perspective. She will present a hypothetical case of an economic evaluation followed by VOI results. She will use the VOI to show how evidence is expected to evolve over time in future, making CED valuable for payers. Saskia Knies, the payer representative, will challenge the work presented by industry with regards to barriers in real practice to achieve the expected value. She will point out the remaining gaps in the evidence development scheme suggested by the industry. Mondher Toumi, the academic HTA expert, will conclude the session by balancing the risks and advantages of using VOI methods in CED agreements. He will advise payers and industries on how to optimally use VOI methods in CED schemes. Finally, we will invite the audience to participate in this discussion by providing feedback and sharing their experience on VOI methods and CED schemes.