PURPOSE:  The workshop will identify gaps in current international guidelines for health economic evaluation in the identification of utility values and the incorporation of these values into economic models. Workshop participants will become familiar with proposed solutions for meeting these gaps based on current best practice and the literature, and critically evaluate these based on their own views and experiences. DESCRIPTION:  The workshop will outline the use of best practice to inform the use of utility values in economic models including estimating utility values for comorbidities and adverse events, and encourage audience participation to inform the debate. Professor Brazier will summarize gaps in international guidelines in economic evaluation for identifying the source of utility values and how these utility values should be incorporated into the economic model. Ms. Ara will use current literature, available recommendations and previous submissions to NICE to propose solutions to filling these gaps, focusing upon 1) obtaining source data using clinical trials and/or systematic reviews, 2) incorporating the identified utility values into the economic model including adjustments for comorbidities, adverse events and baseline evidence. Dr. Chevrou-Severac will discuss the solutions from the perspective of an international pharmaceutical company, and outline the importance of providing transparent and consistent international guidelines for economic models. Fifteen minutes at the end of the session will be devoted to audience participation including critical evaluation of the proposals from participants own experiences to achieve an inclusive and international perspective. Workshop participants will gain further understanding of where gaps exist in international guidelines in the identification and usage of utility values, and contribute to the debate on how to best fill these gaps.