OBJECTIVES: The aim of this study was to asses use, belief and risk awareness among pregnant women attending Ante natal care in Gondar university teaching hospital. METHODS:  Cross sectional study was employed on pregnant women who are attending for antenatal care visit at Gondar university hospital from March 5, 2016 to April 5 2016. Pretested structured interview questionnaire was used for data collection. Binary logistic regression was conducted to identify possible predictable variables associated with influencing the outcome variables. RESULTS: From the total of 423 interview questionnaires, 384 partici­pants (90.8% response rate) were included in the analysis The mean age of participants was 27.22 years, with a standard deviation (SD) of 5.5 years. More than two third of the respondents had 2-3 pregnancy (46.1%) and more than 3 (25.8%) pregnancy histories. One third (33.3%) of the respondents were first trimester pregnant women, 45.6 % and 21.1% were on second trimester and third trimester, respectively. Majority (70%) of respondents think drugs are harmful if taken during pregnancy. Only 4.2 % of the participants never mind to take drugs without advice from professionals, with this regard most (90 %) of the respondents are not willing to take drugs without professional advice. Significant association was found between pregnant women residency and level of education with drug use and risk awareness of medications. Pregnant women from rural are 25% less likely to take medication without prescription paper. An illiterate pregnant women as compared with college and university attendant pregnant women has less risk awareness to drugs that should be avoided during pregnancy AOR 0.126 (0.041, 0.73). CONCLUSIONS:  Women were more conservative to take medications during pregnancy and literacy level affect their belief and drug use practices. Health-care professionals should aware of such attitudes and consider the level of education during counseling.