TREATMENT PATTERNS AND MEDICATION ADHERENCE OF ACUTE ISCHEMIC STROKE PATIENT IN KOREA
Author(s)
Yoon B1, Chung P2, Lee Y3, Shin B4, Kim H5, Cha J6, Kim Y6
1Seoul National University Hospital, Seoul, South Korea, 2Kangbuk Samsung Hospital, Seoul, South Korea, 3Gachon University Gil Medical Center, Incheon, South Korea, 4CHONBUK NATIONAL UNIVERSITY MEDICAL SCHOOL AND HOSPITAL, Jeollabuk-do, South Korea, 5Konkuk University Medical Center, Seoul, South Korea, 6Pfizer Pharmaceuticals Korea Ltd., Seoul, South Korea
OBJECTIVES: Stroke is one of leading causes of death and disability. The treatment of lowering LDL cholesterol is known to have an important impact on the prevention and management of stroke recurrence. It aimed to investigate treatment patterns and medication adherence among acute ischemic stroke patients. METHODS: It was a prospective, multicenter and observational study conducted at nationwide 19 tertiary hospitals from March 2014 to September 2015. Patients who were hospitalized and discharged for either acute Cerebral Ischemic Infarction or Transient Ischemic Attack, in the last 1 month were eligible for participation, and those who were not prescribed with statin at hospital leave were excluded. Demographic and clinical characteristics were examined through a self-administered questionnaire and medical chart review. Medication adherence was assessed both at 3 and 6 months using Morisky Medication Adherence Scales – 8. Adherence levels were categorized as followings; High=8 scores, Moderate=6 to 8 scores, Low< RESULTS: It included 991 patients with mean age of 64.3±12.0, and 65.6% were male. Small vessel occlusion(32.8%) and large artery atherosclerosis(31.3%) were dominant diagnosis, and 20.7% were recurrent patients. At discharge, a majority of the patients were prescribed with statin monotherapy accounting for 978 patients, and 56.8% were prescribed with low dose of statin while others received high dose. The rates of high and moderate adherence were approximately 66% and 26% respectively at each follow-up. At 6 months, a significant difference in total cholesterol was found by adherence levels(High=178.4±42.1mg/dL vs. Moderate=181.6±40.7mg/dL vs. Low=190.4±43.9mg/dL, p=0.0505). The same tendency was found to be present in LDL cholesterol(High=112.0±37.0mg/dL vs. Moderate=115.3±35.6mg/dL vs. Low=123.9±36.9mg/dL, p=0.0134). CONCLUSIONS: The study found there were significant differences in total and LDL cholesterol by different levels of adherence. These results highlight that medication adherence should be taken into account while the treatment of lowering LDL cholesterol for the prevention and effective management of stroke patients.
Conference/Value in Health Info
2016-10, ISPOR Europe 2016, Vienna, Austria
Value in Health, Vol. 19, No. 7 (November 2016)
Code
PCV113
Topic
Patient-Centered Research
Topic Subcategory
Adherence, Persistence, & Compliance
Disease
Cardiovascular Disorders