OBJECTIVES: The adherence to good pharmacy practice(GPP) should be monitor regularly. Barriers to good health care such as poor access to high quality medicine and lack of pharmaceutical care in pharmacy could make welfare loss. In this study we have evaluated the efficacy of pharmacy inspection. METHODS:  Data was collected from inspection forms provided with Vice-Chancellor’s Office in Food & Drugs in Shahid Beheshti University of Medical Sciences and were filled by inspectors between January 2013 and April 2014. 7 major illegal acts including pharmacist absences, non-OTC drugs delivery without prescription, existence of expired drugs, counterfeit drugs or cosmetics, and any illegal narcotic or amphetamine drug, inappropriate drug storage condition, and insufficient consideration in Galenic formulation were assessed in all 26 private pharmacies qualitatively and quantitatively in Pakdasht, Tehran. One inspector filled the inspection forms and the other checked them. The first inspection assumed to be before intervention and the second, third and forth inspection were after intervention. The intervention was regular inspection. RESULTS: In quantitative assessment, for all factors the score of second inspection, were better than the first one in comparison with the other consecutive inspections. According to the qualitative assessment, all malpractices had been decreased entirely comparing the first and the last inspection except prescription drugs delivery and inappropriate preservation condition. CONCLUSIONS: Some malpractices have extreme punishment for example Existence and selling the illegal or counterfeit drugs. Its punishment is at least impounding all the illegal or counterfeit drugs and additional financial penalties. There was no penalty for non-OTC drugs delivery without prescription therefore its score didn't change after intervention. It is concluded that pharmacy inspection could recline malpractices if it is performed routinely and has suitable penalties in recompense for malpractices.