OBJECTIVES: Parenting stress is an important variable to consider in the treatment of asthmatic children, as parents usually take care of their child’s medical symptoms. The aim of this study was to explore the association between parenting stress and the child’s quality of life among parents of asthmatic children. METHODS: An online non-experimental cross-sectional study of parents with children diagnosed with asthma was conducted in 19 asthma/pediatric clinics in Houston, Texas, USA. A pre-tested and validated questionnaire was administered, between November 2015- June 2016 using Qualtrics^®, to evaluate the effect of the child’s quality of life on parenting stress. Also, information was collected about factors that might impact parenting stress, such as family support with children, perceived disease severity, health literacy, and relationship with the physician, along with socio-demographics factors for children and parents. Descriptive and regression analyses were performed using SAS^® 9.3. RESULTS: Of the 262 online completed questionnaires received, 79% of parents were female. The mean age was 35.1 (±8.9) for parents. The distribution by race was: Whites (34.7%), Hispanics (33.2%), African-Americans (25.6%), Asian (3.4%), and other (3.1%). Mean parenting stress scores were 35.9 (±11.9) and ranged from 18 to 86 . Furthermore the average child’s quality of life score was 65 (±17) and ranged from zero to 100. The results of the multiple linear regression analysis indicated negative association between parenting stress and child’s quality of life (β=-0.162, p<0.0151), a negative relationship with the healthcare provider (β=-0.37382, p=0.0096), and a positive relationship with health literacy (β=2.05, p<0.0151) after controlling for family support with children. CONCLUSIONS: Parenting stress is affected by child’s quality of life, health literacy, and the relationship with their healthcare provider. Identifying and treating parental stress is the key to future psychological and physiological diseases and complications associated with parents of asthmatic children.