SYSTEMATIC REVIEW OF QUALITY OF LIFE MEASUREMENT INSTRUMENTS AND RESPONSE CRITERIA AMONG PATIENTS WITH MYELODYSPLASTIC SYNDROMES

Author(s)

Stojkov I1, Rochau U1, Borba HH2, Jevdjevic M3, Koinig K4, Arvandi M1, Efficace F5, Stauder R4, Siebert U6
1UMIT - University for Health Sciences, Medical Informatics and Technology, Institute of Public Health, Medical Decision Making and Health Technology Assessment, Hall i. T., Austria, 2Federal University of Parana, Curitiba, Brazil, 3UMIT - University for Health Sciences, Medical Informatics and Technology, Institute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, Hall i.T., Austria, 4Innsbruck Medical University, Department of Internal Medicine V (Hematology and Oncology), Innsbruck, Austria, 5Health Outcomes Research Unit, Italian Group for Adult Hematologic Diseases (GIMEMA), Rome, Austria, 6and Director, Division for HTA, ONCOTYROL – Center for Personalized Cancer Medicine, Hall i.T., Austria

OBJECTIVES:  Quality-of life (QoL) impacts the prognosis of patients with myelodysplastic syndromes (MDS) and can guide individualized treatment decisions. To develop a new MDS-specific core outcome set (COS) that integrates QoL, we provide a systematic overview of QoL measurement instruments (QoL-MI) and patient-relevant outcomes applied in MDS to date. METHODS: We performed a comprehensive systematic literature search (PubMed, Cochrane Library, Scopus, Web of Science, last updated 01/16) to identify studies applying QoL-MI in MDS patients. In a second review, we searched for studies evaluating MDS patient-relevant outcomes registered from 2012-2016 in the ClinicalTrials.gov database and four clinical trial registries (ISRCTN, ICTRP, EU-CTR, NCI) for the development of the new COS. All studies were screened by at least two independent reviewers (IS/UR/HB/MJ).

Conference/Value in Health Info

2016-10, ISPOR Europe 2016, Vienna, Austria

Value in Health, Vol. 19, No. 7 (November 2016)

Code

PSY119

Topic

Patient-Centered Research

Topic Subcategory

Patient-reported Outcomes & Quality of Life Outcomes

Disease

Systemic Disorders/Conditions

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