OBJECTIVES: Community pharmacies are major contributors to health care systems across the world. Few studies on the economic evaluation of community pharmacist’s Public Health interventions in Portugal have been conducted, most of them disease / intervention specific. This study aimed to estimate the social and economic benefits of current and potential future community pharmacists’ Public Health interventions in Portugal. METHODS: The social and economic value of community pharmacists’ interventions, excluding medication supply, was estimated through a decision-model. Model inputs included effectiveness data, quality of life and health resource consumption obtained from data collected over 25 years in Portuguese pharmacies, from literature review and adapted to Portuguese reality by an expert panel. The estimated economic value was the result of non-remunerated pharmacy interventions plus health resource consumption potentially avoided. Social and economic value of community pharmacists’ interventions derives from the comparison of two scenarios: “with intervention” versus “without intervention”. RESULTS: It is estimated that current community pharmacists’ interventions in Portugal provide a gain in quality of life of 8.3% and an economic value of 879.6 million euros (M€), including 342.1M€ in non-remunerated pharmacy interventions and 448.1M€ in avoided expense with health resource consumption. Interventions to improve adherence and chronic disease interventions in hypertension, diabetes, hyperlipidemia and asthma/COPD generate 54% (474.5 M€) of this benefit. Future community pharmacists’ interventions may provide an additional increase of 6.9% in quality of life and be associated with an economic value of 144.8M€: 120.3M€ in non-remunerated interventions and 24.5M€ in potential savings with health resource consumption. CONCLUSIONS: Community pharmacists’ interventions provide considerable benefit in quality of life and economic value. An increased range of interventions including a greater integration in primary and secondary care, among other transversal interventions, may add further social and economic value to the society.