OBJECTIVES:  It is hypothesised that gender, age and socio-economic status (SES) play key roles in engagement with disease, life-style choices and adherence. This analysis investigated the impact of these non-modifiable factors amongst T2DM patients. METHODS:  Data were drawn from the 2015 Adelphi Diabetes Disease Specific Programme (DSP) in T2DM across 5EU/USA. The DSP is a real-world, cross-sectional survey involving diabetes specialists, primary care physicians (PCPs), and completion of physician-reported forms for the next 10 consulting T2DM patients, with patient-reported forms from the same patients. Key factors analysed were age (<65, 65+), gender and employment status (High-SES: professional/skilled; Low-SES: manual/unemployed) against engagement-lifestyle domains and adherence (Morisky Measurement Adherence Scale; MMAS-8). RESULTS:  A total of 352 specialists and 502 PCPs completed questionnaires for 8368 T2DM patients, of whom 4722 provided patient-reported questionnaires. Females were more likely to be inactive (30%; 24%) and alcohol abstinent (43%; 22%) with similar adherence levels (high MMAS-8 48%; 44%). Older patients were more likely to be inactive (32%; 23%) and alcohol abstinent (38%; 27%) whereas younger patients made more dietary changes (34%; 29%), were active (20%; 13%), had good knowledge of disease (41%; 32%) and often asked questions (41%; 29%) with similar adherence levels (high MMAS-8 45%; 47%). More high-SES patients than Low-SES were more adherent (high MMAS-8 47%; 38%), more likely to make many changes to lifestyle (40%; 27%) and diet (40%; 27%), be very active (24%; 17%) and very engaged in terms of knowledge of disease (17%; 4%), asking questions (51%; 31%) and discussing treatment options (13%; 5%). All results p=<0.05. CONCLUSIONS:  Whilst age and gender differences did not appear to independently affect adherence, there are significant differences in lifestyle factors, knowledge, involvement and adherence between socio-economic groups, suggesting if healthcare practitioners focused on improving disease understanding and education amongst Low-SES patients, adherence could improve.