OBJECTIVES: The incidence of colorectal cancer (CRC) in Slovak Republic is about 3000 cases per year. No study was published about the impact of CRC on quality of life (QoL) and work ability (WA) in patients with CRC in Slovak Republic. METHODS: The sample consisted of 83 patients, 29 women and 54 men, the average age was 67,4 years and weight 74,6 kg. The average duration of disease was 2,73 years. All patients received surgical treatment and 70 had chemotherapy. The patients visited an oncology outpatient clinic 4,82 times a year. The primary method used for analysis was a combined questionnaire consisting of 6 parts: A. Demography, B1. Clinical part, filled out by physician, B2. Clinical part, filled out by patient, C. Quality of life, D. Socio-economic part, E. EQ5DL. F. Special questions. QoL and WA were evaluated on numeric scales from 0 - the worst to 10 - the best. Student-test and chi-squared test were mainly used in results evaluation. RESULTS: Significant statistical differences in values of QoL were found in various stages: in the time of best health – 8,289, without CRC – 6,687, in the time of diagnosis – 4,205 and in the time of full treatment – 2,217. The results of WA evaluation were following: 8,361 vs 6,711 vs 3,735 vs 1,964. The results of evaluations of QoL and WA were in strong correlation. Foreknowledge of disease (1-the worst, 5-the best) was 3,6, satisfaction with medical care – 4,2. Willingness to pay to be healthy was 232,87 € by average monthly income 421,82 €. CONCLUSIONS: CRC has significant impact on patients‘ QoL and WA. In both areas, there are significant differences in patients‘ assessments in various stages of life and the disease. Treatment has no positive impact on QoL and WA in regards to the progressive characteristics of the disease.