PSYCHOMETRIC ANALYSES OF CLINICAL OUTCOME ASSESSMENT (COA) QUESTIONNAIRES DESIGNED TO EVALUATE SATISFACTION WITH PHARMACOLOGICAL STRESS AGENTS (PSAS) USED IN ECHOCARDIOGRAPHY
Author(s)
Spalding J1, Hudgens S2, Litcher-Kelly L3, Shields A3, Kitt T1, Ojo O3, Kristy R1, Lee E1, Mathias A3, Morrissey L3, Houle C1
1Astellas Pharma Global Development, Northbrook, IL, USA, 2Clinical Outcomes Solutions, Tucson, AZ, USA, 3Adelphi Values, Boston, MA, USA
OBJECTIVES: This study examined the psychometric properties of scores from three COAs assessing satisfaction with dobutamine for echocardiography. Previous work documented psychometric properties of these COAs to assess satisfaction with PSAs used with single-photon emission computed tomography myocardial perfusion imaging. METHODS: This evaluation used data from 95 patients and 20 clinicians. Patients completed two questionnaires within 24-hours after the procedure: Patient Satisfaction and Preference Questionnaire (PSPQ) assessing PSA satisfaction, and the Patient Satisfaction Questionnaire (PSQ) assessing satisfaction with the site (for concurrent validity). Physicians completed the Clinician Satisfaction and Preference Questionnaire (CSPQ), and nurses/technicians completed the modified CSPQ (mCSPQ), within 2 weeks of site initiation. RESULTS: Though responses sometimes clustered at either the upper or lower end of item scales, results suggest that patients and clinicians utilized the range of responses available. For PSPQ, floor effects for the “Preparation” and “Reaction to Agent” domains were >40%. Ceiling effects for “Administration” “Effects” and “Overall Satisfaction” domains were also >40%, which implied high levels of satisfaction in these areas. For CSPQ, ceiling effects for “Image Quality” was 33.3%. Internal consistency was strong in most instances [PSPQ: “Preparation” (α=.93), “Reaction to Agent” (α=.40); CSPQ and mCSPQ: “Preparation” (α=.99, .99) and “Administration” (α=.93, .92). Inter-item correlations for PSPQ ranged from -0.01 to 0.96, which are small to strong; CPSQ ranged from 0.15 to 0.96, which are small to strong; mCPSQ ranged from 0.81 to 0.99, which are strong. CONCLUSIONS: Results suggest that when administered in real-world clinical settings, the PSPQ, CPSQ, and mCPSQ are capable of generating scores across the distribution of available responses (though clustering at upper and lower bound was observed in some instances), that are sufficiently reliable for most research purposes.
Conference/Value in Health Info
2016-10, ISPOR Europe 2016, Vienna, Austria
Value in Health, Vol. 19, No. 7 (November 2016)
Code
PRM7
Topic
Clinical Outcomes
Topic Subcategory
Clinical Outcomes Assessment
Disease
Cardiovascular Disorders
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