OBJECTIVES:  Although psoriasis is a chronic disease with many associated comorbidities and a high impact on the patient’s Quality of Life (QoL), its the social and economic impact on patients and Healthcare Systems (HS) is frequently undervalued. There is evidence that characterizes healthcare resource use from a societal and HS perspective but there is scarce information on the patient’s perspective. On the other hand, despite the availability of a number of treatment options, surveys show that patients do not receive the optimal care that is necessary to clear their skin symptoms and to improve their health-related quality of life. PeSsOA study aims to generate data on the burden of PsO in Portugal from patient’s perspective. The main objectives are to characterize the Portuguese psoriasis population, evaluate the impact on patients QoL, social and day-to-day activities, quantify direct and indirect economic burden and characterize patient access to healthcare and use of health resources. METHODS:  Observational cross-sectional study in psoriasis adult patients (≥18 years old). A structured questionnaire was developed in collaboration with the Patients’ National Association, researchers from the Faculty of Pharmacy and Healthcare Professionals, aiming to characterize sociodemographic profile, health behaviors, clinical and therapeutic profile , psoriasis related social impact, QoL and healthcare resource use. QoL is evaluated using DLQI and EQ5D and social impact through analysis of absenteeism, impact on labor activity and family life. Economic impact is evaluated by analysis of healthcare resources consumption and therapeutic related costs. The questionnaire was placed on an online platform. RESULTS:  In terms of sample size, the goal was to recruit approximately 400 patients, considering an estimated Portuguese prevalence of 2% (200.000) and a 95% CI (P<0.05) CONCLUSIONS: Generate data aims to contribute to have a better understanding on the impact of Psoriasis in the patient’s perspective identifying needs and aspirations. (300 words)