OBJECTIVES:  Approximately 20-35% of chronic low back pain (CLBP) patients experience neuropathic pain (NP). The purpose of this study was to develop a conceptual model of symptoms and impacts in subjects with CLBP with NP in the United States (US) and Japan to inform a patient-centered measurement strategy. METHODS:  Centralized IRB approval was obtained. In-person interviews were completed with 35 patients (30=US, 5=Japan). 10/30 subjects in the US were clinically diagnosed with CLBP exclusive of a neuropathic etiology as a control cohort. Interviews were semi-structured and performed until saturation was achieved. Transcripts were analyzed using Atlas.ti. RESULTS:  Participants were predominantly women (n=22, 73.3%) with a median age of 53. The most frequently reported symptoms in CLBP with NP in the US were numbness (n=18, 90.0%), burning (n=14, 70.0%), tingling (n=14, 70.0%), stabbing (n=11, 55.0%), and throbbing (n=11, 55.0%). In Japan, subjects frequently reported numbness and shooting pain (n=4, 80.0% for each). The most frequently reported symptoms in CLBP with nociceptive pain exclusively were aching (n=7, 70.0%) and shocking pain (n=7, 50.0%). Notable differences between NP and nociceptive pain were different pain descriptors: numbness, burning, and tingling were most frequently reported in NP while ache/soreness and shocking pain were most frequently reported in nociceptive patients. Numbness was also reported by 40% of the nociceptive group which suggests that these patients could be experiencing NP. Impacts reported between groups were also similar which included impact on activities of daily living and social/emotional well-being. CONCLUSIONS:  Profiles of CLBP with NP in the US and Japan were generally similar. Based on these findings, researchers can appropriately identify existing measures, determine if modifications are needed, or develop new patient-reported outcome measures to evaluate outcomes in NP associated with CLBP. Patients diagnosed with nociceptive CLBP without a neuropathic component may experience symptoms indicative of undiagnosed NP.