OBJECTIVES:  To explore Drug Information Services at Drug Information Centers practice in Saudi Arabia: with emphasis on Evidence Based Medicine-Therapeutics Guidelines (EBM-TG) System at MOH METHODS:  The survey consisted of 181 questions designed by the authors, seven questions about EBM-TG. It drove from Pharmacy Organizations Standards. This survey distributed to forty five hospital pharmacies that run drug information services in 2015. In this study, the domain Evidence Based Medicine-Therapeutics Guidelines (EBM-TG) System explored and analyzed. RESULTS:  The survey distributed to 45 of hospitals, the response rate, was 40 (88.88%) hospitals. Of that 35 % large hospitals, 37.5 % medium size hospitals, 17.5 % small size hospitals, and 10 % National and Regional Drug Information Centers. Of those; Written policy and procedure for EBM-TG existed only in 18 (45%) of hospitals. EBM-TG Monitoring system is available lived in only 17 (42.5%) hospitals involved 25-100% the elements. The intensive analysis performed for all EBM-TG existed in only 17(42.5%) hospitals ultimately 25-100% used the parts. Notification of treating Physicians of EBM-TG exists in only 17(42.5%) hospitals. There is evidence that the patient receives appropriate care for EBM-TG found in only 18 (45%) hospitals. There is evidence that the EBM-TG Indicators existed in only 19 (45.5%) hospitals found used 25-100% the elements. Process for improving EBM-TG system exists in 20 (50%) hospitals. CONCLUSIONS: There was a poor application of Evidence-Based Medicine-Therapeutics Guidelines in drug information centers practice. Implementation of Evidence-Based Medicine-Therapeutics Guidelines system improves patient outcomes and avoids the unnecessary additional cost in the health care system.