OBJECTIVES: This study was aimed at the comparison of therapeutic outcome of Levonorgestrel Intrauterine System (LNG-IUS) and norethisterone in idiopathic chronic Abnormal Uterine Bleeding (AUB) in the patients of Bahawalpur, Punjab province, Pakistan. METHODS: This study was carried out for six months in the selected clinical settings of Bahawalpur. After recruiting the patients with AUB, they were equally divided into two groups, i.e. group A and B that were treated with LNG-IUS and norethisterone, respectively. A predesigned questionnaire was employed to collect various information like mean age, duration of the disease and parity. Besides, the main outcomes of this treatment was reduction in menstrual blood loss (MBL) that was tested by the PBAC score. The PBAC score was recorded on day 1, 90^th day, and 180^th day after start of therapy. RESULTS: There was statistically non-significant (P > 0.05) difference in the mean age, mean duration of the disease, and the reduction in MBL of both groups after 3 months. After a treatment of 180 days, the reduction in MBL was significantly (P < 0.05) higher in group A (94.74%) than group B patients (73.68%). It shows good treatment response in group A than group B. However, the response of both the treatments showed no association with the patient’s age, parity and chronicity of the disease. CONCLUSIONS: The local population of Bahawalpur, Pakistan suffering from idiopathic chronic AUB can efficiently be treated by using the LNG-IUS than norethisterone; since the former showed potential clinical benefits in terms of reduction in MBL.