ISSUE: Maintaining patient focus in healthcare decision-making is a universally-accepted approach to ensuring positive outcomes. “Value frameworks” share building blocks: health outcomes of interest; evidence to measure effect of treatment on outcomes; combination of outcomes into single health benefit measures; and comparison of care costs with health benefits. ESMO framework is exceptional in excluding costs. Framework developers and health technology assessment (HTA) organizations claim differences in “valuation” tool orientation to patient interests. Even frameworks claiming patient-centricity are criticized for over-emphasizing methods to incorporate payer versus patient perspectives. While tension between payer and patient perspectives is inevitable, many agree frameworks can be improved and diverse interests reconciled therein. Others claim two viewpoints cannot be reconciled in a single framework and (a) separate patient-centric framework(s) developed. OVERVIEW: Moderator will provide a brief overview of existing value frameworks and HTA approaches, characterizing methodology and payer/patient perspective balance. Panelists will critique frameworks/methods on modifications inclusive of patient-focused elements and/or patient-centric use and possibility of reconciling patient and payer interests within a framework. Finally, panelists will debate how addressing payer and patient interests simultaneously could impact research functions: broader evidence generation, patient-reported outcomes development, and establishment of quality measures encompassing payer/patient perspectives.