OBJECTIVES: Stroke is the second leading cause of death behind heart disease, accounting for 10% of total deaths worldwide. Beside disease burden, stroke is also an expensive disease. However researches focusing on stroke-related costs in Vietnam are limited. This study aims to evaluate the inpatient treatment costs of stroke and influencing factors on costs. METHODS: A cross-sectional study was conducted using a randomized sample of stroke inpatients in Ho Chi Minh City 115 People hospital. Stroke patients with full medical record and agreed to attend in the study have been chosen. Foreign patients or patients that did not finish the treatment course in research hospital or died within treatment were eliminated from this study. RESULTS: Study sample included 273 patients with average age at 62.97±0.87 with nearly 60% patients over 60 years old, 56.8% of men and 43.2% of women; 85% with ischemic stroke and 15% with hemorrhagic stroke; 6.17 ± 0.18 days of the length hospital stay. The average total cost per patient was VND 8,112,458.7 ± 285.499,16; in which direct cost was accounted for 77% (VND 6,307,554.5) and indirect cost was 23% (VND 1,804,904.2). In the structure of direct cost, medical cost was 1.22 times higher than non-medical cost (VND 3,470,583.8 and VND 2,836,970.7, respectively). By ingredient of medical direct cost, 60.95% of health services (VND 2,115,264.2), 21.46% of drugs (VND 744,672.1) and 17.59% of emergency services (VND 610,647.5).The influential factors on costs of stroke included age group, the length of hospital stay, the severity and the number of caregivers. CONCLUSIONS: The medical direct cost was the majority part of total cost (42.78%) with hospital stay length of 6.17 ± 0.18 days. With the rising trend of stroke in Vietnam and the high cost burden of treatment, healthcare policies and national medical programs should be considered.