OBJECTIVES: Stroke, also known as cerebrovascular accident, is the second leading cause of death worldwide with 10% of all deaths. The impact of post-stroke on patient is huge not only because of the disease burden but also the medical cost of supportive care. The aim of this study is to evaluate the inpatient care costs of post-stroke in Vietnam based on the data from hosspital of rehabilitation and occupational diseases. METHODS: A retrospective study with database of all patients hospitalized for post-store care with ICD codes I60-I64 that discharged from hospital within 2015. Patients who did not finish the treatment course in research hospital or died within treatment were eliminated from this study. Only medical direct cost has been evaluated. RESULTS: Study sample included 163 patients from hospital database in 2015 with the average age at 65.23±1.19; 63% male; length of hospital stay of 22.65 ± 1.18 days; 69.8% of patients with ischemic stroke and 30.2% with hemorrhagic stroke. The average total post-stroke treatment cost per patient accounted for VND 3,294,046.8 ± 217,354.2; 68.6% of which was covered by health insurance organizations (VND 2,259,681.1) and 31.4% was covered by patients (VND 1,034,364.8). In the structure of cost, the costs of health services were nearly 2 times higher than drug costs (VND 2,191,867.5 vs VND 1,102,179.1; respectively). The length of hospital stay was the main influential factor on costs of post-stroke care. CONCLUSIONS: With hospital stay length of 22.65 ± 1.18 days, the average total cost of post-stroke treatment was VND 3,294,046.8 ± 217,354.2 per patient with the majority part of health services and more than 30% of total costs was paid by patients. More healthcare policies and national medical programs should be considered to reduce the cost burden for stroke patients.