OBJECTIVES:

• Evaluation of the effectiveness of IMMODIN^® by the assessment of documented recurrent infections comparing its incidence during the last year´s period preceding the treatment to the incidence during one year period following the start of the treatment.
• Summarization of the indications for the prescription in routine clinical practice.
• Assessment of the changes in selected immunological parameters, including the laboratory ones. 

METHODS: Non-interventional, multicenter, retrospective study conducted at 18 private or hospital immunology out-patient departments in the Slovak Republic. The evaluation was based on anonymous data collection about adult and pediatric patients obtained from routine clinical practice of the out-patient departments; the patients had to receive at least one dose of IMMODIN^®between February 2012 and September 2014. The results of routinely performed medical examinations and information about used immunomodulatory therapy, were collected for a period of 12 months prior and after the first IMMODIN^®administration. RESULTS: In total, 133 patients (48 male (36,1%) and 85 female (63,9%)) fulfilled inclusion criteria and their data has been collected. The most frequently reported indications involved recurrent chronic infections (27,2%), followed by chronic fatigue syndrome (22,4%) and severe states of allergic origin with a proven defective cellular immunity (7,1%). Evaluation of the effectiveness parameters confirmed a statistically significant decrease in the absolute number of respiratory (p<0,0001), urogenital and skin infections (p<0,05). CONCLUSIONS: The recurrent infection is one of the main reason why patients having immunodeficiency seek medical attention. The presence of recurrent infections decrease the quality of life. The treatment using IMMODIN^® significantly lowered the frequency of recurrent respiratory, urogenital or skin infection incidence. Therefore the treatment of patients with recurrent infection using IMMODIN^® seems to be valuable alternative to improve their health outcomes and to increase their quality of life.