OBJECTIVES:  This study was conducted to identify the drug related problems (DRPs) in patients undergoing hemodialysis for chronic kidney failure. METHODS:  This was a prospective, observational and interventional study conducted at dialysis unit of the tertiary care teaching hospital in the rural area. The patients with stage III-V chronic kidney failure were enrolled in the study. All the enrolled patients were followed on their scheduled visits of hemodialysis. Medical records, treatment charts and patient interview were sources of data collection. Clinical Pharmacist reviewed treatment chart of enrolled patients and identify DRPs. Identified DRPs were reviewed and discussed with concerned clinicians. Interventions were made to concerned health care professionals to resolve all the identified DRPs. All the DRPs were documented electronically for further assessment of its nature, extent, possible cause(s) and its acceptance by concerned clinicians. RESULTS:  A total of 156 DRPs were identified from 482 medication orders of CONCLUSIONS:  Structured and dedicated pharmacotherapy approaches by clinical pharmacists can help in early detection and prevention of DRPs. Clinical pharmacist interventions were accepted and appreciated by clinicians.