OBJECTIVES:  Primary health care setting (PHCS) episodes can be classified using the International Classification of Primary Care (ICPC). However, health-related quality of life (HRQoL) research based on episodes has been scarce although e.g. cost-utility models would benefit from episode-based HRQoLs. Furthermore, PHCS HRQoL has been rarely studied for multiple episode chapters although many patients initiate their episode in PHCS and PHCS HRQoL is needed to capture full treatment path or episode. We study PHCS HRQoL and 3-months effectiveness classified according to the ICPC-2 chapters. METHODS:  During Effective Health Centre Study three health centre’s (Pirkanmaa, Finland) unselected patients (N 519) filled EQ-5D-3L questionnaire. British time trade-off value set was used. HRQoL score difference between three months and baseline measurements was effectiveness. The minimum clinically important difference (MID) was considered to be 0.07. All analyses were done with Stata MP 14.1. RESULTS:  Mean baseline and three month EQ-5D-3L scores for all responders were 0.74 and 0.78, respectively. Respective mean scores for patients answering to both measurements were 0.75 and 0.78. The lowest (0.64) mean baseline score was observed for patients with ICPC-2 chapter L: Musculoskeletal. The highest (0.84) mean baseline score was observed for patients with X: Female genital. The highest effectiveness (0.13) was observed for patients with D: Digestive and worst deterioration (-0.06) for patients with P: Psychological. The MID effectiveness was gained also for H: Ear, L: Musculoskeletal, R: Respiratory, and T: Endocrine, metabolic and nutritional. Effectiveness was significant for D: Digestive, L: Musculoskeletal and R: respiratory. The lowest (0.62) mean 3-month score was observed for patients with N: Neurological. The highest (0.88) mean 3-month score was observed for patients with H: Ear. CONCLUSIONS: Different episodes demonstrate different HRQoL. Episode-based PHCS HRQoL is an important – yet, rarely done – element of real world health services research that should be incorporated in cost-utility models.