OBJECTIVES:  Health-related quality of life (HRQoL) is an increasingly important outcome measure in the course of physical therapy. For this reason, HRQoL assessment is used by the German Social Accident Insurance at the beginning and during the course of physical rehabilitation for patients injured after accidents. However, less is known about the perspective of clinicians working in the field. In an ongoing study, we assess the benefit of using standardized HRQoL assessment and the impact of a clinician training program regarding the assessment and interpretation of HRQOL measurements. METHODS:  We invited leading clinicians from 31 physical rehabilitation centers to take part in a training program which should enable the participants to interpret the results of HRQoL assessment. All clinicians in these centers were asked to complete a questionnaire regarding their knowledge of HRQoL measurement and applying results to therapy before and sometime after the training program. RESULTS:  Overall, 236 clinicians completed the questionnaire. Nearly half of them (n=113) are working in rehabilitations centers which take part in an existing assessment program, the other half (n=123) was newly recruited. Overall, participants of experienced centers showed better knowledge about HRQoL measurement instruments and feel more certain in decision situations (experienced/inexperienced): e.g. decision of therapy extension (67% / 58%), decision of therapy plan (88% / 76%). Informal feedback during the training program confirmed that HRQoL results enabled clinicians to better understand patients’ behaviors and added information for therapy decisions. This was especially important for patients with severe and complicated cases. CONCLUSIONS:  These findings illustrate the relevance of HRQoL measurement in the course of physical therapy. We found benefits in treatment decision making for clinics that historically used standardized HRQoL measurements even before participating in the training program. Using HRQoL measures to aid therapy decisions may be especially important for patients with complicated situations or severe disease.