OBJECTIVES: Evidence-based and successful policy requires making investment decisions - on all level of health care investments - should be based on objective and verifiable methods. Health technology assessment (HTA) plays an important role in evidence-based decision-making and by the help of HTA optimal health outcomes and efficient use of available resources could be achieved. METHODS: A literature review was conducted to define the number of health care investments that was introduced to Hungary between 2010 and 2015 and real, independent HTA Department managed assessments were introduced with validated methods to define the effects of investments on long-term from policy point of view. The aim of the literature review was also to show the opportunities of the involvement of HTA Department, Hungary into the coming EU or member state financed projects e.g. in primary care, screening or public health programs to avoid developing diabetes and the need for expensive interventions. RESULTS: According to the literature review the role of HTA is more and more important in all level of decision making. Despite the investment decision making and assessment of programs are not based on HTA. The Hungarian HTA Department was not involved into any program assessment till the end of 2015 when the Health Services Management Training Centre (HSMTC) of Semmelweis University initiated a cooperation aiming the HTA of diabetes, hypertension and smoking interventions of the Public Health focused Primary Care Model Program of the Swiss-Hungarian Cooperation. CONCLUSIONS: More transparency in EU financed health-care related programs ensure an unbiased decision-making process. By the help of the HTA Department of National Institute of Pharmacy and Nutrition, Hungary conducted CE analysis a well-established methodology should be used, transparency and value for money should be ensured. In cooperation with the HSMTC now it is ongoing with diabetes, hypertension and smoking in the focus.